Death Stranding uses the concept of chiralty as a major theme, and as always, Kojima dived deep into it
The chiral crystals that can be collected are shaped like hands
Hands are another major theme, and according to Wikipedia
- The word chirality is derived from the Greek χειρ ( kheir ), “hand,” a familiar chiral object.)
The fear Sam has from being touched, Aphenphosmphobia, is closely related to Chirophobia, the fear of hands (https://www.vg247.com/2019/11/08/death-stranding-aphenphosmphobia-chiral/)