I don’t think there are any major differences with layout in a different OS. I’m a windows user and I would say go with whatever OS you are most comfortable with in the long run because you go beyond the gamedev tutorial eventually and into your own projects.
Gamedev are usually good at highlighting the differences as you are learning from their tutorials for any subject matter, where specific buttons are different etc. but even if that wasn’t the case, you looking for that alternative button or how something works in your OS vs the Os being used in the tutorial, may help make the learning stick more. You are more likely to remember a solution or method of doing something that you search for yourself than copying from a tutorial. That is just my own personal preference and how I learn. I remember doing one of their old Unity 4.0 tutorials in Unity 5+ and there were quite a lot of differences, but me searching for those solutions myself helped my learning massively.
When it comes to you graduating the tutorial and you want to work on your own stuff, you will be in a much better position to hit the ground running in your preferred OS if you have already been working in it before.