UE 5.1 is not a release and so the course cannot be guaranteed to work with it as we won’t have tested it.
Saying that, there does seem to be a bug with 5.1 when you use the blank level which I found myself when exploring a basic VR setup with blueprint. Start with the VR Template which I’d recommend that anyway and you should be fine.
Now, regarding using the VR Template vs the blank template. There’s an issue with the blank template when using VR and this is unrelated to 5.1 and it means performance is really poor. I think the default settings are different than the VR Template but I couldn’t locate anything. However, the blank template stutters and crashes, in 5.0.3 and obviously there’s issues right off with 5.1 as well.
So, we can support 5.0.3 with the course and when 5.1 is finally released, I’ll test it and identify any problems. I won’t be able to provide much help with 5.1 until then so I suggest you stick with the current release version.