Optymising file size

Hi Guys,
I’m playing with blender for some time and it can be a great fun. However I have an issue with large files, 200MB and more like. I use powerful enough Mac Pro but even for him it’s too much sometimes. I’m creating a scene made of hounders of individual elements (human body cells) and at some stage the computer just slows down and has problems wth handling the graphic. Is there anything, any trick I should know and which makes life easier. Anything to optimise the file size while working on it? I will be grateful for any help. Cheers.

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